Structure of PDB 1feb Chain B

Receptor sequence
>1febB (length=484) Species: 5656 (Crithidia fasciculata) [Search protein sequence]
SRAYDLVVIGAGSGGLEAGWNAASLHKKRVAVIDLQKHHGPPHYAALGGT
CVNVGCVPKKLMVTGANYMDTIRESAGFGWELDRESVRPNWKALIAAKNK
AVSGINDSYEGMFADTEGLTFHQGFGALQDNHTVLVRESADPNSAVLETL
DTEYILLATGSWPQHLGIEGDDLCITSNEAFYLDEAPKRALCVGGGYISI
EFAGIFNAYKARGGQVDLAYRGDMILRGFDSELRKQLTEQLRANGINVRT
HENPAKVTKNADGTRHVVFESGAEADYDVVMLAIGRVPRSQTLQLEKAGV
EVAKNGAIKVDAYSKTNVDNIYAIGDVTDRVMLTPVAINEGAAFVDTVFA
NKPRATDHTKVACAVFSIPPMGVCGYVEEDAAKKYDQVAVYESSFTPLMH
NISGSTYKKFMVRIVTNHADGEVLGVHMLGDSSPEIIQSVAICLKMGAKI
SDFYNTIGVHPTSAEELCSMRTPAYFYEKGKRVE
3D structure
PDB1feb X-Ray Structure of Trypanothione Reductase from Crithidia Fasciculata at 2.4-A Resolution
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S13 L47 C51 C56 K59 R84 E85 Y197 E201 I338 G458 H460 E465 E484
Catalytic site (residue number reindexed from 1) S13 L47 C51 C56 K59 R84 E85 Y197 E201 I338 G458 H460 E465 E484
Enzyme Commision number 1.8.1.12: trypanothione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B I9 G10 G12 S13 G14 D34 A45 T50 C51 G55 C56 K59 G126 T159 G160 Y197 I198 R286 R289 G325 D326 M332 L333 T334 I9 G10 G12 S13 G14 D34 A45 T50 C51 G55 C56 K59 G126 T159 G160 Y197 I198 R286 R289 G325 D326 M332 L333 T334
Gene Ontology
Molecular Function
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0015036 disulfide oxidoreductase activity
GO:0015042 trypanothione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1feb, PDBe:1feb, PDBj:1feb
PDBsum1feb
PubMed
UniProtP39040|TYTR_CRIFA Trypanothione reductase (Gene Name=TPR)

[Back to BioLiP]