Structure of PDB 1fap Chain B

Receptor sequence
>1fapB (length=95) Species: 9606 (Homo sapiens) [Search protein sequence]
RVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKE
TSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRIS
3D structure
PDB1fap Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAP B L2031 S2035 F2039 W2101 Y2105 F2108 L14 S18 F22 W84 Y88 F91 BindingDB: IC50=>10000nM,Kd=0.600000nM
Gene Ontology
Molecular Function
GO:0044877 protein-containing complex binding

View graph for
Molecular Function
External links
PDB RCSB:1fap, PDBe:1fap, PDBj:1fap
PDBsum1fap
PubMed8662507
UniProtP42345|MTOR_HUMAN Serine/threonine-protein kinase mTOR (Gene Name=MTOR)

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