Structure of PDB 1f7k Chain B

Receptor sequence
>1f7kB (length=117) Species: 11673 (Feline immunodeficiency virus) [Search protein sequence]
MIIEGDGILDKRSEDAGYDLLAAKEIHLLPGEVKVIPTGVKLMLPKGYWG
LIIGKSSIGSKGLDVLGGVIDEGYRGEIGVIMINVSRKSITLMERQKIAQ
LIILPCKHEVLEQGKVV
3D structure
PDB1f7k Structures of feline immunodeficiency virus dUTP pyrophosphatase and its nucleotide complexes in three crystal forms.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A216 K255 S257 D264 D271
Catalytic site (residue number reindexed from 1) A16 K55 S57 D64 D71
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.-
3.6.1.23: dUTP diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP B G268 V269 D271 Y274 G279 G68 V69 D71 Y74 G79 MOAD: Ki=15uM
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004170 dUTP diphosphatase activity
Biological Process
GO:0006226 dUMP biosynthetic process
GO:0046081 dUTP catabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1f7k, PDBe:1f7k, PDBj:1f7k
PDBsum1f7k
PubMed10957629
UniProtP16088|POL_FIVPE Pol polyprotein (Gene Name=pol)

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