Structure of PDB 1f0x Chain B

Receptor sequence

>1f0xB (length=502) Species: 562 (Escherichia coli) [Search protein sequence]

NKAFLNELARLVGSSHLLTDPAKTARYRKGFRSGQGDALAVVFPGSLLEL
WRVLKACVTADKIILMQAANTGLTEGSTPNGNDYDRDVVIISTLRLDKLH
VLGKGEQVLAYPGTTLYSLEKALKPLGREPHSVIGSSCIGASVIGGICNN
SGGSLVQRGPAYTEMSLFARINEDGKLTLVNHLGIDLGETPEQILSKLDD
DRIKDDDVRHDGRHAHDYDYVHRVRDIEADTPARYNADPDRLFESSGCAG
KLAVFAVRLDTFEAEKNQQVFYIGTNQPEVLTEIRRHILANFENLPVAGE
YMHRDIYDIAELPPRMKNWRDKYEHHLLLKMAGDGVGEAKSWLVDYFKQA
EGDFFVCTPEEGSKAFLHRFAAAGAAIRYQAVHSDEVEDILALDIALRRN
DTEWYEHLPPEIDSQLVHKLYYGHFMCYVFHQDYIVKKGVDVHALKEQML
ELLQQRGAQYPAEHNVGHLYKAPETLQKFYRENDPTNSMNPGIGKTSKRK
NW

3D structure

PDB

1f0x The crystal structure of D-lactate dehydrogenase, a peripheral membrane respiratory enzyme.

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.5.12: D-lactate dehydrogenase (quinone).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	B	F1039 M1074 A1076 A1077 N1078 T1079 G1080 L1081 G1084 S1085 I1142 G1143 S1144 S1150 I1152 C1156 S1159 G1160 A1257 G1258 L1260 V1262 E1528 H1529	F31 M66 A68 A69 N70 T71 G72 L73 G76 S77 I134 G135 S136 S142 I144 C148 S151 G152 A249 G250 L252 V254 E463 H464

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0016901	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0048038	quinone binding
GO:0050660	flavin adenine dinucleotide binding
GO:0071949	FAD binding
GO:0102029	D-lactate dehydrogenase (quinone) activity

	Biological Process
GO:0006089	lactate metabolic process
GO:0009060	aerobic respiration
GO:0009061	anaerobic respiration
GO:0022904	respiratory electron transport chain
GO:0055085	transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1f0x, PDBe:1f0x, PDBj:1f0x
PDBsum	1f0x
PubMed	10944213
UniProt	P06149\|DLD_ECOLI Quinone-dependent D-lactate dehydrogenase (Gene Name=dld)

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