Structure of PDB 1ezf Chain B

Receptor sequence
>1ezfB (length=324) Species: 9606 (Homo sapiens) [Search protein sequence]
NSLSNSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFYLVLRALDTLE
DDMTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFR
NLAEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGL
SRLFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQ
EVWSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQ
SVFNFCAIPQVMAIATLAACYNNQQVFKGAVATNMPAVKAIIYQYMEEIY
HRIPDSDPSSSKTRQIISTIRTQN
3D structure
PDB1ezf Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis.
ChainB
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y171 R218 R228 F288
Catalytic site (residue number reindexed from 1) Y138 R185 R195 F255
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IN0 B S51 S53 F54 Y73 L76 V179 G180 L183 L211 F288 S18 S20 F21 Y40 L43 V146 G147 L150 L178 F255
Gene Ontology
Molecular Function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1ezf, PDBe:1ezf, PDBj:1ezf
PDBsum1ezf
PubMed10896663
UniProtP37268|FDFT_HUMAN Squalene synthase (Gene Name=FDFT1)

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