Structure of PDB 1ex0 Chain B

Receptor sequence
>1ex0B (length=716) Species: 9606 (Homo sapiens) [Search protein sequence]
RTAFGGRRAVPPNNSNAAEDDLPTVELQGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYP
QENKGTYIPVPIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRM
YVAVWTPYGVLRTSRNPETDTYILFNPWCEDDAVYLDNEKEREEYVLNDI
GVIFYGEVNDIKTRSWSYGQFEDGILDTCLYVMDRAQMDLSGRGNPIKVS
RVGSAMVNAKDDEGVLVGSFDNIYAYGVPPSAWTGSVDILLEYRSSENPV
RYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRC
GPASVQAIKHGHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATH
IGKLIVTKQIGGDGMMDITDTYKFQEGQEEERLALETALMYGAKKPLNTS
RSNVDMDFEVENAVLGKDFKLSITFRNNSHNRYTITAYLSANITFYTGVP
KAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLLEQASLHFFVTARINE
TRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKETLRNVW
VHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSL
RHVYGELDVQIQRRPS
3D structure
PDB1ex0 Identification of the Calcium Binding Site and a Novel Ytterbium Site in Blood Coagulation Factor XIII by X-Ray Crystallography
ChainB
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F279 C314 H373 D396 Y560
Catalytic site (residue number reindexed from 1) F270 C305 H364 D387 Y546
Enzyme Commision number 2.3.2.13: protein-glutamine gamma-glutamyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B N436 S437 D438 A457 N427 S428 D429 A448
Gene Ontology
Molecular Function
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0007596 blood coagulation
GO:0018149 peptide cross-linking
GO:0072378 blood coagulation, fibrin clot formation
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0031093 platelet alpha granule lumen
GO:0062023 collagen-containing extracellular matrix
GO:0072562 blood microparticle
GO:1990234 transferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ex0, PDBe:1ex0, PDBj:1ex0
PDBsum1ex0
PubMed
UniProtP00488|F13A_HUMAN Coagulation factor XIII A chain (Gene Name=F13A1)

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