Structure of PDB 1ewq Chain B

Receptor sequence
>1ewqB (length=749) Species: 271 (Thermus aquaticus) [Search protein sequence]
MEGMLKGEGPGPLPPLLQQYVELRDQYPDYLLLFQVGDFYECFGEDAERL
ARALGLVLTHKTSKDFTTPMAGIPLRAFEAYAERLLKMGFRLAVADQVEP
VRREVTQLLTPGTLLQESLLPREANYLAAIATGDGWGLAFLDVSTGEFKG
TVLKSKSALYDELFRHRPAEVLLAPELLENGAFLDEFRKRFPVMLSEAPF
EPEGEGPLALRRARGALLAYAQRTQGGALSLQPFRFYDPGAFMRLPEATL
RALEVFEPLRGQDTLFSVLDETRTAPGRRLLQSWLRHPLLDRGPLEARLD
RVEGFVREGALREGVRRLLYRLADLERLATRLELGRASPKDLGALRRSLQ
ILPELRALLGEEVGLPDLSPLKEELEAALVEDPPLKVSEGGLIREGYDPD
LDALRAAHREGVAYFLELEERERERTGIPTLKVGYNAVFGYYLEVTRPYY
ERVPKEYRPVQTLKDRQRYTLPEMKEKEREVYRLEALIRRREEEVFLEVR
ERAKRQAEALREAARILAELDVYAALAEVAVRYGYVRPRFGDRLQIRAGR
HPVVERRTEFVPNDLEMAHELVLITGPNMAGKSTFLRQTALIALLAQVGS
FVPAEEAHLPLFDGIYTRIGAGKSTFMVEMEEVALILKEATENSLVLLDE
VGRGTSSLDGVAIATAVAEALHERRAYTLFATHYFELTALGLPRLKNLHV
AAREEAGGLVFYHQVLPGPASKSYGVEVAAMAGLPKEVVARARALLQAM
3D structure
PDB1ewq Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B V1445 T1453 P1455 D1472 R1473 V438 T446 P448 D465 R466
BS02 dna B P1015 L1016 K1064 V1108 R1110 L1470 K1471 R1475 P15 L16 K64 V101 R103 L463 K464 R468
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006281 DNA repair
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:1ewq, PDBe:1ewq, PDBj:1ewq
PDBsum1ewq
PubMed11048710
UniProtQ56215|MUTS_THEAQ DNA mismatch repair protein MutS (Gene Name=mutS)

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