Structure of PDB 1esn Chain B

Receptor sequence
>1esnB (length=309) Species: 562 (Escherichia coli) [Search protein sequence]
LMTPYLQFDRNQWAALRDSVPMTLSEDEIARLKGINEDLSLEEVAEIYLP
LSRLLNFYISSNLRRQAVLEQFLGTNGQRIPYIISIAGSVAVGKSTTARV
LQALLSRWPEHRRVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLV
KFVSDLKSGVPNVTAPVYSHLIYDVIPDGDKTVVQPDILILEGLNVLQSG
MDYPHDPHHVFVSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDS
YFHNYAKLTKEEAIKTAMTLWKEINWLNLKQNILPTRERASLILTKSANH
AVEEVRLRK
3D structure
PDB1esn Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP B N43 D45 V97 A98 G100 K101 S102 T103 R243 H307 N36 D38 V90 A91 G93 K94 S95 T96 R236 H300
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0050165 pantetheine kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1esn, PDBe:1esn, PDBj:1esn
PDBsum1esn
PubMed10862768
UniProtP0A6I3|COAA_ECOLI Pantothenate kinase (Gene Name=coaA)

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