Structure of PDB 1err Chain B

Receptor sequence
>1errB (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYASMMGLLTNLADRELVHMINWAKR
VPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRN
QGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYLEEK
DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM
EHLYSMKLYDLLLEMLDAHRLHA
3D structure
PDB1err Molecular basis of agonism and antagonism in the oestrogen receptor.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RAL B T347 A350 D351 E353 L354 W383 L391 F404 I424 H524 L525 T34 A37 D38 E40 L41 W70 L78 F91 I111 H202 L203 BindingDB: IC50=1.8nM,EC50=2.4nM,Ki=0.37nM
External links
PDB RCSB:1err, PDBe:1err, PDBj:1err
PDBsum1err
PubMed9338790
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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