Structure of PDB 1ep3 Chain B

Receptor sequence
>1ep3B (length=261) Species: 1358 (Lactococcus lactis) [Search protein sequence]
SQLQEMMTVVSQREVAYNIFEMVLKGTLVDEMDLPGQFLHLAVPNGAMLL
RRPISISSWDKRAKTCTILYRIGDETTGTYKLSKLESGAKVDVMGPLGNG
FPVAEVTSTDKILIIGGGIGVPPLYELAKQLEKTGCQMTILLGFASENVK
ILENEFSNLKNVTLKIATDDGSYGTKGHVGMLMNEIDFEVDALYTCGAPA
MLKAVAKKYDQLERLYISMESRMACGIGACYACVEHDKEDESHALKVCED
GPVFLGKQLSL
3D structure
PDB1ep3 Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.3.1: Transferred entry: 1.3.98.1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B L51 R53 P54 I55 S56 L70 Y71 T78 G79 T80 I120 E221 S222 R223 L50 R52 P53 I54 S55 L69 Y70 T77 G78 T79 I119 E220 S221 R222
BS02 FES B M224 C226 G227 G229 C231 Y232 C234 C249 M223 C225 G226 G228 C230 Y231 C233 C248
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0009055 electron transfer activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ep3, PDBe:1ep3, PDBj:1ep3
PDBsum1ep3
PubMed11188687
UniProtP56968|PYRK_LACLM Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit (Gene Name=pyrK)

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