Structure of PDB 1ekb Chain B

Receptor sequence
>1ekbB (length=235) Species: 9913 (Bos taurus) [Search protein sequence]
IVGGSDSREGAWPWVVALYFDDQQVCGASLVSRDWLVSAAHCVYGRNMEP
SKWKAVLGLHMASNLTSPQIETRLIDQIVINPHYNKRRKNNDIAMMHLEM
KVNYTDYIQPICLPEENQVFPPGRICSIAGWGALIYQGSTADVLQEADVP
LLSNEKCQQQMPEYNITENMVCAGYEAGGVDSCQGDSGGPLMCQENNRWL
LAGVTSFGYQCALPNRPGVYARVPRFTEWIQSFLH
3D structure
PDB1ekb Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H41 D92 Q184 G185 D186 S187 G188
Enzyme Commision number 3.4.21.9: enteropeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B A26 W27 W29 D116 P120 C122 R206 W207 A11 W12 W14 D106 P110 C112 R198 W199
BS02 peptide B H57 K99 Y174 D189 S190 S195 S214 F215 G216 H41 K89 Y164 D181 S182 S187 S206 F207 G208
BS03 ZN B H57 E126 S195 H41 E116 S187
BS04 ZN B D50 H243 D34 H235
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1ekb, PDBe:1ekb, PDBj:1ekb
PDBsum1ekb
PubMed10493881
UniProtP98072|ENTK_BOVIN Enteropeptidase (Gene Name=TMPRSS15)

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