Structure of PDB 1ebd Chain B

Receptor sequence
>1ebdB (length=455) Species: 1422 (Geobacillus stearothermophilus) [Search protein sequence]
AIETETLVVGAGPGGYVAAIRAAQLGQKVTIVEKGNLGGVCLNVGCIPSK
ALISASHRYEQAKHSEEMGIKAENVTIDFAKVQEWKASVVKKLTGGVEGL
LKGNKVEIVKGEAYFVDANTVRVVNGDSAQTYTFKNAIIATGSRPIELPN
FKFSNRILDSTGALNLGEVPKSLVVIGGGYIGIELGTAYANFGTKVTILE
GAGEILSGFEKQMAAIIKKRLKKKGVEVVTNALAKGAEEREDGVTVTYEA
NGETKTIDADYVLVTVGRRPNTDELGLEQIGIKMTNRGLIEVDQQCRTSV
PNIFAIGDIVPGPALAHKASYEGKVAAEAIAGHPSAVDYVAIPAVVFSDP
ECASVGYFEQQAKDEGIDVIAAKFPFAANGRALALNDTDGFLKLVVRKED
GVIIGAQIIGPNASDMIAELGLAIEAGMTAEDIALTIHAHPTLGEIAMEA
AEVAL
3D structure
PDB1ebd Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P19 L43 C47 C52 S55 N80 V81 Y186 E190 S326 H444 H446 E451
Catalytic site (residue number reindexed from 1) P13 L37 C41 C46 S49 N74 V75 Y180 E184 S320 H438 H440 E445
Enzyme Commision number 1.8.1.4: dihydrolipoyl dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B G18 P19 E39 K40 V46 C47 G51 C52 K56 E118 A119 T147 G148 Y186 I187 R274 D314 A320 L321 A322 G12 P13 E33 K34 V40 C41 G45 C46 K50 E112 A113 T141 G142 Y180 I181 R268 D308 A314 L315 A316
Gene Ontology
Molecular Function
GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1ebd, PDBe:1ebd, PDBj:1ebd
PDBsum1ebd
PubMed8805537
UniProtP11959|DLDH1_GEOSE Dihydrolipoyl dehydrogenase (Gene Name=pdhD)

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