Structure of PDB 1e8h Chain B

Receptor sequence
>1e8hB (length=545) Species: 69488 (Penicillium simplicissimum) [Search protein sequence]
EFRPLTLPPKLSLSDFNEFIQDIIRIVGSENVEVISMKPTHTHDPTHVMD
QDYFLASAIVAPRNVADVQSIVGLANKFSFPLWPISIGRNSGYGGAAPRV
SGSVVLDMGKNMNRVLEVNVEGAYCVVEPGVTYHDLHNYLEANNLRDKLW
LDVPDLGGGSVLGNAVERGVGYTPYGDHWMMHSGMEVVLANGELLRTGMG
ALPDPKRPETMGLKPEDQPWSKIAHLFPYGFGPYIDGLFSQSNMGIVTKI
GIWLMPNPGGYQSYLITLPKDGDLKQAVDIIRPLRLGMALQNVPTIRHIL
LDAAVLGDKRSYSSRTEPLSDEELDKIAKQLNLGRWNFYGALYGPEPIRR
VLWETIKDAFSAIPGVKFYFPEDTPENSVLRVRDKTMQGIPTYDELKWID
WLPNGAHLFFSPIAKVSGEDAMMQYAVTKKRCQEAGLDFIGTFTVGMREM
HHIVCIVFNKKDLIQKRKVQWLMRTLIDDCAANGWGEYRTHLAFMDQIME
TYNWNNSSFLRFNEVLKNAVDPNGIIAPGKSGVWPSQYSHVTWKL
3D structure
PDB1e8h Structural Analysis of Flavinylation in Vanillyl-Alcohol Oxidase
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y108 D170 E182 D192 D317 V397 E410 I414 H422 H466 Y503 R504 K545
Catalytic site (residue number reindexed from 1) Y93 D155 E167 D177 D302 V382 E395 I399 H407 H451 Y488 R489 K530
Enzyme Commision number 1.1.3.38: vanillyl-alcohol oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B S101 I102 G103 R104 S175 E182 I261 V262 K545 S86 I87 G88 R89 S160 E167 I246 V247 K530
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004458 D-lactate dehydrogenase (cytochrome) activity
GO:0008720 D-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0018465 vanillyl-alcohol oxidase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0015945 methanol metabolic process
GO:1903457 lactate catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005777 peroxisome

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Cellular Component
External links
PDB RCSB:1e8h, PDBe:1e8h, PDBj:1e8h
PDBsum1e8h
PubMed10984479
UniProtP56216|VAOX_PENSI Vanillyl-alcohol oxidase (Gene Name=VAOA)

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