Structure of PDB 1e7w Chain B

Receptor sequence
>1e7wB (length=258) Species: 5664 (Leishmania major) [Search protein sequence]
VPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARR
PNSAITVQADLSNVATAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFY
PTPLLRGDREAMETATADLFGSNAIAPYFLIKAFAHRVAGTPAKHRGTNY
SIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGP
GLSVLVDWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVD
GGYSLTRA
3D structure
PDB1e7w Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites.
ChainB
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R17 D181 Y194
Catalytic site (residue number reindexed from 1) R12 D157 Y170
Enzyme Commision number 1.5.1.33: pteridine reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B R17 L18 H36 H38 R39 S40 D65 L66 N109 A110 S111 M179 K198 P224 S227 R12 L13 H31 H33 R34 S35 D60 L61 N95 A96 S97 M155 K174 P200 S203
BS02 MTX B S111 F113 Y191 Y194 W238 H241 S97 F99 Y167 Y170 W208 H211 BindingDB: Ki=180nM
Gene Ontology
Molecular Function
GO:0004155 6,7-dihydropteridine reductase activity
GO:0016491 oxidoreductase activity
GO:0047040 pteridine reductase activity
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
GO:0031427 response to methotrexate
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1e7w, PDBe:1e7w, PDBj:1e7w
PDBsum1e7w
PubMed11373620
UniProtQ01782|PTR1_LEIMA Pteridine reductase 1 (Gene Name=PTR1)

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