Structure of PDB 1e3a Chain B

Receptor sequence
>1e3aB (length=560) Species: 562 (Escherichia coli) [Search protein sequence]
PTGSNMWVIGKSKAQDAKAIMVNGPQFGWYAPAYTYGIGLHGAGYDVTGN
TPFAYPGLVFGHNGVISWGSTAGFGDDVDIFAERLSAEKPGYYLHNGKWV
KMLSREETITVKNGQAETFTVWRTVHGNILQTDQTTQTAYAKSRAWDGKE
VASLLAWTHQMKAKNWQEWTQQAAKQALTINWYYADVNGNIGYVHTGAYP
DRQSGHDPRLPVPGTGKWDWKGLLPFEMNPKVYNPQSGYIANWNNSPQKD
YPASDLFAFLWGGADRVTEIDRLLEQKPRLTADQAWDVIRQTSRQDLNLR
LFLPTLQAATSGLTQSDPRRQLVETLTRWDGINLLNDDGKTWQQPGSAIL
NVWLTSMLKRTVVAAVPMPFDKWYSASGYETTQDGPTGSLNISVGAKILY
EAVQGDKSPIPQAVDLFAGKPQQEVVLAALEDTWETLSKRYGNNVSNWKT
PAMALTFRANNFFGVPQAAAEETRHQAEYQNRGTENDMIVFSPTTSDRPV
LAWDVVAPGQSGFIAPDGTVDKHYEDQLKMYENFGRKSLWLTKQDVEAHK
ESQEVLHVQR
3D structure
PDB1e3a Structure of a Slow Processing Precursor Penicillin Acylase from Escherichia Coli Reveals the Linker Peptide Blocking the Active-Site Cleft
ChainB
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S264 Q286 A332 N504 N746
Catalytic site (residue number reindexed from 1) S4 Q26 A72 N244 N486
Enzyme Commision number 3.5.1.11: penicillin amidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D336 V338 D339 P468 D515 D76 V78 D79 P208 D255
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1e3a, PDBe:1e3a, PDBj:1e3a
PDBsum1e3a
PubMed10993730
UniProtP06875|PAC_ECOLX Penicillin G acylase (Gene Name=pac)

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