Structure of PDB 1dy8 Chain B

Receptor sequence

>1dy8B (length=175) Species: 31645 (Hepatitis C virus (isolate Taiwan)) [Search protein sequence]

APITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNG
VCWTVYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPVSYLKGSSGGPLLCPSGHV
VGIFRAAVCTRGVAKAVDFIPVESM

3D structure

PDB

1dy8 Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes

Chain

Resolution

2.4 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H57 D81 G137 S139
Catalytic site (residue number reindexed from 1)	H57 D81 G137 S139
Enzyme Commision number	2.7.7.48: RNA-directed RNA polymerase. 3.4.21.98: hepacivirin. 3.4.22.- 3.6.1.15: nucleoside-triphosphate phosphatase. 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 G23 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 R92	T4 A5 Y6 S7 Q8 T10 R11 C16 T19 S20 G23 D30 E32 V33 Q34 V35 L36 S37 K62 T63 L64 R92
BS02	0F7	B	H57 R123 K136 G137 S139 F154 R155 A156 A157 D168	H57 R123 K136 G137 S139 F154 R155 A156 A157 D168

Gene Ontology

	Molecular Function
GO:0008236	serine-type peptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0019087	transformation of host cell by virus

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Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1dy8, PDBe:1dy8, PDBj:1dy8
PDBsum	1dy8
PubMed	10702283
UniProt	P26662\|POLG_HCVJA Genome polyprotein

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