Structure of PDB 1dv2 Chain B

Receptor sequence
>1dv2B (length=448) Species: 562 (Escherichia coli) [Search protein sequence]
HMLDKIVIANRGEIALRILRACKELGIKTVAVHSSADRDLKHVLLADETV
CIGPAPSVKSYLNIPAIISAAEITGAVAIHPGYGFLSENANFAEQVERSG
FIFIGPKAETIRLMGDKVSAIAAMKKAGVPCVPGSDGPLGDDMDKNRAIA
KRIGYPVIIKASGGGGGRGMRVVRGDAELAQSISMTRAEAKAAFSNDMVY
MEKYLENPRHVEIQVLADGQGNAIYLAERDCSMQRRHQKVVEEAPAPGIT
PELRRYIGERCAKACVDIGYRGAGTFEFLFENGEFYFIKMNTRIQVEHPV
TEMITGVDLIKEQLRIAAGQPLSIKQEEVHVRGHAVECRINAEDPNTFLP
SPGKITRFHAPGGFGVRWESHIYAGYTVPPYYDSMIGKLICYGENRDVAI
ARMKNALQELIIDGIKTNVDLQIRIMNDENFQHGGTNIHYLEKKLGLQ
3D structure
PDB1dv2 Movement of the biotin carboxylase B-domain as a result of ATP binding.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K116 K159 D196 H209 R235 T274 E276 K288 N290 R292 E296 R338
Catalytic site (residue number reindexed from 1) K117 K160 D197 H210 R236 T275 E277 K289 N291 R293 E297 R339
Enzyme Commision number 6.3.4.14: biotin carboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP B K116 K159 G163 G165 M169 E201 Y203 L204 H236 L278 K288 K117 K160 G164 G166 M170 E202 Y204 L205 H237 L279 K289
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0004075 biotin carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:2001295 malonyl-CoA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009317 acetyl-CoA carboxylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1dv2, PDBe:1dv2, PDBj:1dv2
PDBsum1dv2
PubMed10821865
UniProtP24182|ACCC_ECOLI Biotin carboxylase (Gene Name=accC)

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