Structure of PDB 1dtw Chain B

Receptor sequence
>1dtwB (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
QTQKMNLFQSVTSALDNSLAKDPTAVIFGEDVAFGGVFRCTVGLRDKYGK
DRVFNTPLCEQGIVGFGIGIAVTGATAIAEIQFADYIFPAFDQIVNEAAK
YRYRSGDLFNCGSLTIRSPWGCVGHGALYHSQSPEAFFAHCPGIKVVIPR
SPFQAKGLLLSCIEDKNPCIFFEPKILYRAAAEEVPIEPYNIPLSQAEVI
QEGSDVTLVAWGTQVHVIREVASMAKEKLGVSCEVIDLRTIIPWDVDTIC
KSVIKTGRLLISHEAPLTGGFASEISSTVQEECFLNLEAPISRVCGYDTP
FPHIFEPFYIPDKWKCYDALRKMINY
3D structure
PDB1dtw Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E76 H146
Catalytic site (residue number reindexed from 1) E60 H130
Enzyme Commision number 1.2.4.4: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K B G128 S129 L130 T131 C178 I179 D181 N183 P184 C185 G112 S113 L114 T115 C162 I163 D165 N167 P168 C169
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:1dtw, PDBe:1dtw, PDBj:1dtw
PDBsum1dtw
PubMed10745006
UniProtP21953|ODBB_HUMAN 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (Gene Name=BCKDHB)

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