Structure of PDB 1dqn Chain B

Receptor sequence
>1dqnB (length=230) Species: 5741 (Giardia intestinalis) [Search protein sequence]
MICSVTGKPVKDVLSTFFKDRNDVLESEVKKFHLLATFEECKALAADTAR
RMNEYYKDVAEPVTLVALLTGAYLYASLLTVHLTFPYTLHFVKVSSYKGT
RQESVVFDEEDLKQLKEKREVVLIDEYVDSGHTIFSIQEQIKHAKICSCF
VKDVDAIKKHSALADTKMFYGYTPMPKGSWLIGFGLDDNGLRRGWAHLFD
INLSESEVTEFRRRLTEHIKGLNINGVNRY
3D structure
PDB1dqn Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 A(,).
ChainB
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMU B D125 E126 Y127 D129 S130 G131 T133 W180 L181 D125 E126 Y127 D129 S130 G131 T133 W180 L181 MOAD: Ki=10nM
BS02 POP B L69 T70 G71 R193 L69 T70 G71 R193
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005829 cytosol

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External links
PDB RCSB:1dqn, PDBe:1dqn, PDBj:1dqn
PDBsum1dqn
PubMed10841757
UniProtQ24973

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