Structure of PDB 1doh Chain B

Receptor sequence
>1dohB (length=271) Species: 148305 (Pyricularia grisea) [Search protein sequence]
YDAIPGPLGPQSASLEGKVALVTGAGRGIGREMAMELGRRGCKVIVNYAN
STESAEEVVAAIKKNGSDAACVKANVGVVEDIVRMFEEAVKIFGKLDIVC
SNSGVVSFGHVKDVTPEEFDRVFTINTRGQFFVAREAYKHLEIGGRLILM
GSITGQAKAVPKHAVYSGSKGAIETFARCMAIDMADKKITVNVVAPGGIK
TDMYHAVCREYIPNGENLSNEEVDEYAAVQWSPLRRVGLPIDIARVVCFL
ASNDGGWVTGKVIGIDGGACM
3D structure
PDB1doh Structures of trihydroxynaphthalene reductase-fungicide complexes: implications for structure-based design and catalysis.
ChainB
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G40 S164 H175 Y178 K182 Y223
Catalytic site (residue number reindexed from 1) G28 S152 H163 Y166 K170 Y211
Enzyme Commision number 1.1.1.252: tetrahydroxynaphthalene reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B G36 R39 G40 I41 A61 N62 S63 N87 V88 N114 S115 G116 M162 K182 P208 I211 T213 M215 G24 R27 G28 I29 A49 N50 S51 N75 V76 N102 S103 G104 M150 K170 P196 I199 T201 M203
BS02 NID B Y178 G210 Y216 C220 Y223 M283 Y166 G198 Y204 C208 Y211 M271 MOAD: Ki=2.4nM
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
GO:0047039 tetrahydroxynaphthalene reductase activity
Biological Process
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1doh, PDBe:1doh, PDBj:1doh
PDBsum1doh
PubMed11342131
UniProtQ12634|T4HR_PYRO7 Tetrahydroxynaphthalene reductase (Gene Name=MGG_02252)

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