Structure of PDB 1dma Chain B

Receptor sequence
>1dmaB (length=189) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
FLGDGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQS
IVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQIRNGALLRVYVPRSSL
PGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEEGGRLETILGW
PLAERTVVIPSAIPTDPRNVDLDPSSIPDKEQAISALPD
3D structure
PDB1dma The crystal structure of Pseudomonas aeruginosa exotoxin domain III with nicotinamide and AMP: conformational differences with the intact exotoxin.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E553
Catalytic site (residue number reindexed from 1) E145
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NCA B H440 G441 Y470 I471 Y481 E553 H41 G42 Y71 I72 Y82 E145
BS02 AMP B H440 T442 A446 S449 I450 R456 R458 F469 H41 T43 A47 S50 I51 R57 R59 F70
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1dma, PDBe:1dma, PDBj:1dma
PDBsum1dma
PubMed7568123
UniProtP11439|TOXA_PSEAE Exotoxin A (Gene Name=eta)

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