Structure of PDB 1d6s Chain B

Receptor sequence
>1d6sB (length=322) [Search protein sequence]
SKIYEDNSLTIGHTPLVRLNRIGNGRILAKVESRNPSFSVACRIGANMIW
DAEKRGVLKPGVELVEPTNGNTGIALAYVAAARGYKLTLTMPETMSIERR
KLLKALGANLVLTEGAKGMKGAIQKAEEIVASDPQKYLLLQQFSNPANPE
IHEKTTGPEIWEDTDGQVDVFISGVGTGGTLTGVTRYIKGTKGKTDLITV
AVEPTDSPVIAQALAGEEIKPGPHKIQGIGAGFIPGNLDLKLIDKVVGIT
NEEAISTARRLMEEEGILAGISSGAAVAAALKLQEDESFTNKNIVVILPS
SGERYLSTALFADLFTEKELQQ
3D structure
PDB1d6s Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A41 G228
Catalytic site (residue number reindexed from 1) A41 G228
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B N71 G176 T177 G178 T180 G228 S272 P299 N71 G176 T177 G178 T180 G228 S272 P299
BS02 MET B T68 N69 N71 T72 Q142 F143 G176 G228 T68 N69 N71 T72 Q142 F143 G176 G228
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Biological Process
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Cellular Component
External links
PDB RCSB:1d6s, PDBe:1d6s, PDBj:1d6s
PDBsum1d6s
PubMed10452898
UniProtP0A1E3|CYSK_SALTY Cysteine synthase A (Gene Name=cysK)

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