Structure of PDB 1d1g Chain B

Receptor sequence
>1d1gB (length=164) Species: 2336 (Thermotoga maritima) [Search protein sequence]
AKVIFVLAMDVSGKIASSVESWSSFEDRKNFRKITTEIGNVVMGRITFEE
IGRPLPERLNVVLTRRPKTSNNPSLVFFNGSPADVVKFLEGKGYERVAVI
GGKTVFTEFLREKLVDELFVTVEPYVFGKGIPFFDEFEGYFPLKLLEMRR
LNERGTLFLKYSVE
3D structure
PDB1d1g The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.
ChainB
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP B L7 A8 I15 G44 R45 I46 T47 E50 L63 T64 R65 I100 G101 G102 K103 T104 I131 L7 A8 I15 G44 R45 I46 T47 E50 L63 T64 R65 I100 G101 G102 K103 T104 I131
BS02 MTX B V6 L7 A8 D27 R28 F31 I51 L55 R58 I100 V6 L7 A8 D27 R28 F31 I51 L55 R58 I100
Gene Ontology
Molecular Function
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Cellular Component
External links
PDB RCSB:1d1g, PDBe:1d1g, PDBj:1d1g
PDBsum1d1g
PubMed10731419
UniProtQ60034|DYR_THEMA Dihydrofolate reductase (Gene Name=folA)

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