Structure of PDB 1cq1 Chain B

Receptor sequence

>1cq1B (length=446) Species: 471 (Acinetobacter calcoaceticus)

DVPLTPSQFAKAKSENFDKKVILSNLNKPHALLWGPDNQIWLTERATGKI
LRVNPESGSVKTVFQVPEIVNDADGQNGLLGFAFHPDFKNNPYIYISGTF
KNPKPNQTIIRRYTYNKSTDTLEKPVDLLAGLPSSKDHQSGRLVIGPDQK
IYYTIGDQGRNQLAYLFLPNQAQHTPTQQELNGKDYHTYMGKVLRLNLDG
SIPKDNPSFNGVVSHIYTLGHRNPQGLAFTPNGKLLQSEQGPNSDDEINL
IVKGGNYGWPNVAGYKDDSGYAYANYSAAANKSIKDLAQNGVKVAAGVPV
TKESEWTGKNFVPPLKTLYTVQDTYNYNDPTCGEMTYICWPTVAPSSAYV
YKGGKKAITGWENTLLVPSLKRGVIFRIKLDPTYSTTYDDAVPMFKSNNR
YRDVIASPDGNVLYVLTDTAGNVQKDDGSVTNTLENPGSLIKFTYK

3D structure

• PDB: 1cq1 Structure and mechanism of soluble quinoprotein glucose dehydrogenase.
• Chain: B
• Resolution: 1.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H144 D163 R228 A269 Y271 D273 E309
• Catalytic site (residue number reindexed from 1): H138 D157 R222 A263 Y265 D267 E303
• Enzyme Commision number: 1.1.5.2: quinoprotein glucose dehydrogenase (PQQ, quinone).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BGC	B	D143 H144 Q168 Y343	D137 H138 Q162 Y337
BS02	CA	B	E253 Y263	E247 Y257
BS03	CA	B	A269 Y271 D273 E309	A263 Y265 D267 E303
BS04	CA	B	G247 P248	G241 P242
BS05	PQQ	B	Q76 H144 R228 N229 Q246 Y343 T348 A350 L376 K377 R406 R408	Q76 H138 R222 N223 Q240 Y337 T342 A344 L370 K371 R400 R402

Gene Ontology

Molecular Function

• GO:0008876 quinoprotein glucose dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

External links

• PDB: RCSB:1cq1, PDBe:1cq1, PDBj:1cq1
• PDBsum: 1cq1
• PubMed: 10508152
• UniProt: P13650|DHGB_ACICA Quinoprotein glucose dehydrogenase B (Gene Name=gdhB)