Structure of PDB 1cjv Chain B

Receptor sequence
>1cjvB (length=188) Species: 10116 (Rattus norvegicus) [Search protein sequence]
HQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSK
PKFSGVEKIKTIGSTYMAATGLSARQYMHIGTMVEFAYALVGKLDAINKH
SFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKI
QVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNT
3D structure
PDB1cjv Two-metal-Ion catalysis in adenylyl cyclase.
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S891 I892 S942 R1029 K1065
Catalytic site (residue number reindexed from 1) S13 I14 S64 R140 K176
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DAD B K938 D1018 S1028 R1029 K1065 K60 D129 S139 R140 K176
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1cjv, PDBe:1cjv, PDBj:1cjv
PDBsum1cjv
PubMed10427002
UniProtP26769|ADCY2_RAT Adenylate cyclase type 2 (Gene Name=Adcy2)

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