Structure of PDB 1cjt Chain B

Receptor sequence
>1cjtB (length=189) Species: 10116 (Rattus norvegicus) [Search protein sequence]
YHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLS
KPKFSGVEKIKTIGSTYMAATGLSARQYMHIGTMVEFAYALVGKLDAINK
HSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDK
IQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNT
3D structure
PDB1cjt Two-metal-Ion catalysis in adenylyl cyclase.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S891 I892 S942 R1029 K1065
Catalytic site (residue number reindexed from 1) S14 I15 S65 R141 K177
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FOK B F895 S942 F18 S65
BS02 DAD B K938 D1018 S1028 R1029 K1065 K61 D130 S140 R141 K177
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1cjt, PDBe:1cjt, PDBj:1cjt
PDBsum1cjt
PubMed10427002
UniProtP26769|ADCY2_RAT Adenylate cyclase type 2 (Gene Name=Adcy2)

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