Structure of PDB 1cjk Chain B

Receptor sequence
>1cjkB (length=190) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLL
SKPKFSGVEKIKTIGSTYMAATGLSARQYMHIGTMVEFAYALVGKLDAIN
KHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD
KIQVTEETSLILQTLGYTCTCRGIINVKGKGDLKTYFVNT
3D structure
PDB1cjk Two-metal-Ion catalysis in adenylyl cyclase.
ChainB
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S891 I892 S942 R1029 K1065
Catalytic site (residue number reindexed from 1) S15 I16 S66 R142 K178
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TAT B D1018 V1024 N1025 R1029 D131 V137 N138 R142
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1cjk, PDBe:1cjk, PDBj:1cjk
PDBsum1cjk
PubMed10427002
UniProtP26769|ADCY2_RAT Adenylate cyclase type 2 (Gene Name=Adcy2)

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