Structure of PDB 1bhx Chain B

Receptor sequence
>1bhxB (length=147) Species: 9606 (Homo sapiens) [Search protein sequence]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKET
3D structure
PDB1bhx Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102
Catalytic site (residue number reindexed from 1) H43 D99
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B F34 R67 R73 T74 R75 Y76 F19 R62 R68 T69 R70 Y71
BS02 R56 B H57 Y60A E97A H43 Y47 E94 PDBbind-CN: -logKd/Ki=6.84,Ki=0.145uM
BindingDB: Ki=145nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1bhx, PDBe:1bhx, PDBj:1bhx
PDBsum1bhx
PubMed9733491
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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