Structure of PDB 1b66 Chain B

Receptor sequence
>1b66B (length=138) Species: 10117 (Rattus rattus) [Search protein sequence]
LRRRARLSRLVSFSASHRLHSPSLSAEENLKVFGKCNNPNGHGHNYKVVV
TIHGEIDPVTGMVMNLTDLKEYMEEAIMKPLDHKNLDLDVPYFADVVSTT
ENVAVYIWENLQRLLPVGALYKVKVYETDNNIVVYKGE
3D structure
PDB1b66 Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
ChainB
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H23 C42 H48 H50 D88 H89 E133
Catalytic site (residue number reindexed from 1) H17 C36 H42 H44 D82 H83 E127
Enzyme Commision number 4.2.3.12: 6-pyruvoyltetrahydropterin synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H23 H48 H50 H17 H42 H44
BS02 BIO B L25 C42 T105 T106 E107 E133 L19 C36 T99 T100 E101 E127
Gene Ontology
Molecular Function
GO:0003874 6-pyruvoyltetrahydropterin synthase activity
GO:0016829 lyase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006729 tetrahydrobiopterin biosynthetic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1b66, PDBe:1b66, PDBj:1b66
PDBsum1b66
PubMed10024455
UniProtP27213|PTPS_RAT 6-pyruvoyl tetrahydrobiopterin synthase (Gene Name=Pts)

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