Structure of PDB 1b55 Chain B

Receptor sequence
>1b55B (length=162) Species: 9606 (Homo sapiens) [Search protein sequence]
AAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGS
KKGSIDVEKITCVETVVPEKNPPPERQISEMEQISIIERFPYPFQVVYDE
GPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQT
AKNAMGCQILEN
3D structure
PDB1b55 Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H143 C154 C165 H135 C146 C157
BS02 4IP B K12 S14 Q15 Q16 K17 K18 S21 N24 R28 Y39 K53 K11 S13 Q14 Q15 K16 K17 S20 N23 R27 Y38 K52 MOAD: Kd=40nM
PDBbind-CN: -logKd/Ki=7.40,Kd=40nM
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:1b55, PDBe:1b55, PDBj:1b55
PDBsum1b55
PubMed10196129
UniProtQ06187|BTK_HUMAN Tyrosine-protein kinase BTK (Gene Name=BTK)

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