Structure of PDB 1b48 Chain B

Receptor sequence
>1b48B (length=221) Species: 10090 (Mus musculus) [Search protein sequence]
AAKPKLYYFNGRGRMESIRWLLAAAGVEFEEEFLETREQYEKMQKDGHLL
FGQVPLVEIDGMMLTQTRAILSYLAAKYNLYGKDLKERVRIDMYADGTQD
LMMMIAVAPFKTPKEKEESYDLILSRAKTRYFPVFEKILKDHGEAFLVGN
QLSWADIQLLEAILMVEELSAPVLSDFPLLQAFKTRISNIPTIKKFLQPG
SQRKPPPDGPYVEVVRIVLKF
3D structure
PDB1b48 Crystal structure of a murine glutathione S-transferase in complex with a glutathione conjugate of 4-hydroxynon-2-enal in one subunit and glutathione in the other: evidence of signaling across the dimer interface.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y9 R15 R20
Catalytic site (residue number reindexed from 1) Y8 R14 R19
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH B Y41 G53 Q54 V55 Q67 T68 Y40 G52 Q53 V54 Q66 T67
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1b48, PDBe:1b48, PDBj:1b48
PDBsum1b48
PubMed10508391
UniProtP24472|GSTA4_MOUSE Glutathione S-transferase A4 (Gene Name=Gsta4)

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