Structure of PDB 1b3r Chain B

Receptor sequence
>1b3rB (length=428) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCL
HMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKG
ETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGIS
EETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIK
RATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAM
EGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDV
EIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHP
SFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNV
KLTKLTEKQAQYLGMPINGPFKPDHYRY
3D structure
PDB1b3r Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H54 S77 S82 D130 E155 N180 K185 D189 N190 C194 H300 H352 S360 Q364
Catalytic site (residue number reindexed from 1) H51 S74 S79 D127 E152 N177 K182 D186 N187 C191 H297 H349 S357 Q361
Enzyme Commision number 3.13.2.1: adenosylhomocysteinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B K425 Y429 K422 Y426
BS02 NAD B D189 N190 C194 G221 D222 V223 E242 I243 T274 T275 I280 I298 G299 H300 N345 H352 D186 N187 C191 G218 D219 V220 E239 I240 T271 T272 I277 I295 G296 H297 N342 H349
Gene Ontology
Molecular Function
GO:0004013 adenosylhomocysteinase activity
GO:0005507 copper ion binding
GO:0016787 hydrolase activity
GO:0030554 adenyl nucleotide binding
GO:0042802 identical protein binding
GO:0051287 NAD binding
GO:0098604 adenosylselenohomocysteinase activity
Biological Process
GO:0001666 response to hypoxia
GO:0002439 chronic inflammatory response to antigenic stimulus
GO:0006730 one-carbon metabolic process
GO:0007584 response to nutrient
GO:0019510 S-adenosylhomocysteine catabolic process
GO:0033353 S-adenosylmethionine cycle
GO:0042745 circadian sleep/wake cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0042470 melanosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1b3r, PDBe:1b3r, PDBj:1b3r
PDBsum1b3r
PubMed10387078
UniProtP10760|SAHH_RAT Adenosylhomocysteinase (Gene Name=Ahcy)

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