Structure of PDB 1b12 Chain B

Receptor sequence
>1b12B (length=211) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence]
FIYEPFQIPSGSMMPTLLIGDFILVEKFGHPKRGDIVVFKYPEDPKLDYI
KRAVGLPGDKVTYDPVSKELTIQPGCCENALPVTYSNVEPSDFVQTFSRE
ATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQVGMYYQQ
PGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRATAIWMSF
DLRLSRIGGIH
3D structure
PDB1b12 Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor.
ChainB
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S88 S90 K145 S278
Catalytic site (residue number reindexed from 1) S10 S12 K51 S175
Enzyme Commision number 3.4.21.89: signal peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1PN B I86 P87 S88 S90 Y143 I144 K145 S278 A279 I8 P9 S10 S12 Y49 I50 K51 S175 A176
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:1b12, PDBe:1b12, PDBj:1b12
PDBsum1b12
PubMed9823901
UniProtP00803|LEP_ECOLI Signal peptidase I (Gene Name=lepB)

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