Structure of PDB 1ay4 Chain B

Receptor sequence
>1ay4B (length=389) Species: 266 (Paracoccus denitrificans) [Search protein sequence]
MLGNLKPQLALMGEFRADPRQGKIDLGVGVYKDATGHTPIMRAVHAAEQR
MLETETTKTYAGLSGEPEFQKAMGELILGDGLKSETTATLATVGGTGALR
QALELARMANPDLRVFVSDPTWPNHVSIMNFMGLPVQTYRYFDAETRGVD
FEGMKADLAAAKKGDMVLLHGCCHNPTGANLTLDQWAEIASILEKTGALP
LIDLAYQGFGDGLEEDAAGTRLIASRIPEVLIAASCSKNFGIYRERTGCL
LALCADAATRELAQGAMAFLNRQTYSFPPFHGAKIVSTVLTTPELRADWM
AELEAVRSGMLRLREQLAGELRDLSGSDRFGFVAEHRGMFSRLGATPEQV
KRIKEEFGIYMVGDSRINIAGLNDNTIPILARAIIEVGV
3D structure
PDB1ay4 Crystal structures of Paracoccus denitrificans aromatic amino acid aminotransferase: a substrate recognition site constructed by rearrangement of hydrogen bond network.
ChainB
Resolution2.33 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W140 D222 A224 K258
Catalytic site (residue number reindexed from 1) W122 D203 A205 K238
Enzyme Commision number 2.6.1.57: aromatic-amino-acid transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP B G108 T109 W140 N194 D222 A224 Y225 S255 S257 K258 R266 G95 T96 W122 N175 D203 A205 Y206 S235 S237 K238 R246
Gene Ontology
Molecular Function
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004838 L-tyrosine-2-oxoglutarate transaminase activity
GO:0008483 transaminase activity
GO:0008793 aromatic-amino-acid transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0080130 L-phenylalanine-2-oxoglutarate transaminase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0009058 biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0033585 L-phenylalanine biosynthetic process from chorismate via phenylpyruvate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1ay4, PDBe:1ay4, PDBj:1ay4
PDBsum1ay4
PubMed9665848
UniProtP95468|TYRB_PARDE Aromatic-amino-acid aminotransferase (Gene Name=tyrB)

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