Structure of PDB 1arz Chain B

Receptor sequence
>1arzB (length=269) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NIRVAIAGAGGRMGRQLIQAALALEGVQLGAALEREGSSLLGSDAGELAG
AGKTGVTVQSSLDAVKDDFDVFIDFTRPEGTLNHLAFCRQHGKGMVIGTT
GFDEAGKQAIRDAAADIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIE
IIEAHHRHKVDAPSGTALAMGEAIAHALDKDLKDCAVYSREGHTGERVPG
TIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAVRSALWL
SGKESGLFDMRDVLDLNNL
3D structure
PDB1arz Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.
ChainB
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H159 K163
Catalytic site (residue number reindexed from 1) H155 K159
Enzyme Commision number 1.17.1.8: 4-hydroxy-tetrahydrodipicolinate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAI B G12 G14 G15 R16 M17 E38 F79 T80 R81 G84 H88 G102 T104 A127 N128 F129 F243 G8 G10 G11 R12 M13 E34 F75 T76 R77 G80 H84 G98 T100 A123 N124 F125 F239
BS02 PDC B T104 H160 K163 S168 G169 T170 F243 T100 H156 K159 S164 G165 T166 F239
Gene Ontology
Molecular Function
GO:0008839 4-hydroxy-tetrahydrodipicolinate reductase
GO:0016491 oxidoreductase activity
GO:0016726 oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0019877 diaminopimelate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1arz, PDBe:1arz, PDBj:1arz
PDBsum1arz
PubMed9398235
UniProtP04036|DAPB_ECOLI 4-hydroxy-tetrahydrodipicolinate reductase (Gene Name=dapB)

[Back to BioLiP]