Structure of PDB 1aor Chain B

Receptor sequence

>1aorB (length=605) Species: 2261 (Pyrococcus furiosus)

MYGNWGRFIRVNLSTGDIKVEEYDEELAKKWLGSRGLAIYLLLKEMDPTV
DPLSPENKLIIAAGPLTGTSAPTGGRYNVVTKSPLTGFITMANSGGYFGA
ELKFAGYDAIVVEGKAEKPVYIYIKDEHIEIRDASHIWGKKVSETEATIR
KEVGSEKVKIASIGPAGENLVKFAAIMNDGHRAAGRGGVGAVMGSKNLKA
IAVEGSKTVPIADKQKFMLVVREKVNKLRNDPVAGGGLPKYGTAVLVNII
NENGLYPVKNFQTGVYPYAYEQSGEAMAAKYLVRNKPCYACPIGCGRVNR
LPTVGETEGPEYESVWALGANLGINDLASIIEANHMCDELGLDTISTGGT
LATAMELYEKGHIKDEELGDAPPFRWGNTEVLHYYIEKIAKREGFGDKLA
EGSYRLAESYGHPELSMTVKKLELPAYDPRGAEGHGLGYATNNRGGCHIK
NYMISPEILGYPYKMDPHDVSDDKIKMLILFQDLTALIDSAGLCLFTTFG
LGADDYRDLLNAALGWDFTTEDYLKIGERIWNAERLFNLKAGLDPARDDT
LPKRFLEEPMPEGPNKGHTVRLKEMLPRYYKLRGWTEDGKIPKEKLEELG
IAEFY

3D structure

• PDB: 1aor Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase.
• Chain: B
• Resolution: 2.3 Å

Enzymatic activity

• Enzyme Commision number: 1.2.7.5: aldehyde ferredoxin oxidoreductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FE	B	E332 H383	E332 H383
BS02	SF4	B	R76 C288 C291 I293 C295 C494 F496	R76 C288 C291 I293 C295 C494 F496
BS03	PTE	B	R76 A92 N93 G95 R182 A183 A184 G185 R186 E311 D338 L342 D343 T344 R444 H448 I449 K450 D489 C494 L495 F496	R76 A92 N93 G95 R182 A183 A184 G185 R186 E311 D338 L342 D343 T344 R444 H448 I449 K450 D489 C494 L495 F496

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
• GO:0033726 aldehyde ferredoxin oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

External links

• PDB: RCSB:1aor, PDBe:1aor, PDBj:1aor
• PDBsum: 1aor
• PubMed: 7878465
• UniProt: Q51739|AOR_PYRFU Tungsten-containing aldehyde ferredoxin oxidoreductase (Gene Name=aor)