Structure of PDB 1aog Chain B

Receptor sequence
>1aogB (length=483) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
IFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCV
NVGCVPKKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKNLIAVKDEAV
LNINKSYDEMFRDTEGLEFFLGWGSLESKNVVNVRESADPASAVKERLET
EHILLASGSWPHMPNIPGIEHCISSNEAFYLPEPPRRVLTVGGGFISVEF
AGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELTKQLTANGIQILTKE
NPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNAGVMI
KNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTTP
RKTDHTRVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHKVS
GSKYKTFVAKIITNHSDGTVLGVHLLGDNAPEIIQGIGICLKLNAKISDF
YNTIGVHPTSAEELCSMRTPSYYYVKGEKMEKP
3D structure
PDB1aog The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S15 L49 C53 C58 K61 R86 T87 F199 E203 I339 G459 H461 E466 E485 K486
Catalytic site (residue number reindexed from 1) S11 L45 C49 C54 K57 R82 T83 F195 E199 I335 G455 H457 E462 E481 K482
Enzyme Commision number 1.8.1.12: trypanothione-disulfide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD B I11 G12 G14 S15 G16 D36 V37 S47 G51 T52 C53 V56 G57 C58 K61 W127 G128 A160 S161 G162 F199 R288 R291 G326 D327 M333 L334 T335 I7 G8 G10 S11 G12 D32 V33 S43 G47 T48 C49 V52 G53 C54 K57 W123 G124 A156 S157 G158 F195 R284 R287 G322 D323 M329 L330 T331
Gene Ontology
Molecular Function
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0015036 disulfide oxidoreductase activity
GO:0015042 trypanothione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1aog, PDBe:1aog, PDBj:1aog
PDBsum1aog
PubMed8771196
UniProtP28593|TYTR_TRYCR Trypanothione reductase (Gene Name=TPR)

[Back to BioLiP]