Structure of PDB 1ahh Chain B

Receptor sequence
>1ahhB (length=253) Species: 562 (Escherichia coli) [Search protein sequence]
MFNSDNLRLDGKCAIITGAGAGIGKEIAITFATAGASVVVSDINADAANH
VVDEIQQLGGQAFACRCDITSEQELSALADFAISKLGKVDILVNNAGGGG
PKPFDMPMADFRRAYELNVFSFFHLSQLVAPEMEKNGGGVILTITSMAAE
NKNINMTSYASSKAAASHLVRNMAFDLGEKNIRVNGIAPGAILTDALKSV
ITPEIEQKMLQHTPIRRLGQPQDIANAALFLCSPAASWVSGQILTVSGGG
VQE
3D structure
PDB1ahh Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli.
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G22 S146 M156 Y159 K163
Catalytic site (residue number reindexed from 1) G22 S146 M156 Y159 K163
Enzyme Commision number 1.1.1.159: 7alpha-hydroxysteroid dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD B G18 I23 D42 I43 D68 I69 N95 I144 K163 P189 G190 I192 G18 I23 D42 I43 D68 I69 N95 I144 K163 P189 G190 I192
Gene Ontology
Molecular Function
GO:0008709 cholate 7-alpha-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0051287 NAD binding
GO:0106281 chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
Biological Process
GO:0016042 lipid catabolic process
GO:0030573 bile acid catabolic process
Cellular Component
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Cellular Component
External links
PDB RCSB:1ahh, PDBe:1ahh, PDBj:1ahh
PDBsum1ahh
PubMed8672472
UniProtP0AET8|HDHA_ECOLI 7alpha-hydroxysteroid dehydrogenase (Gene Name=hdhA)

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