Structure of PDB 1aer Chain B

Receptor sequence
>1aerB (length=195) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
FLGDGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQS
IVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDRGRIRNGALLR
VYVPRSSLPGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPRLETI
LGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALPDY
3D structure
PDB1aer Crystal structure of the catalytic domain of Pseudomonas exotoxin A complexed with a nicotinamide adenine dinucleotide analog: implications for the activation process and for ADP ribosylation
ChainB
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E553
Catalytic site (residue number reindexed from 1) E148
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TIA B H440 G441 Y470 Y481 E553 H41 G42 Y71 Y82 E148
BS02 AMP B H440 T442 A446 I450 R456 R458 F469 H41 T43 A47 I51 R57 R59 F70
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1aer, PDBe:1aer, PDBj:1aer
PDBsum1aer
PubMed8692916
UniProtP11439|TOXA_PSEAE Exotoxin A (Gene Name=eta)

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