Structure of PDB 1ab8 Chain B

Receptor sequence
>1ab8B (length=176) Species: 10116 (Rattus norvegicus) [Search protein sequence]
EELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDD
LLSKPKFSGVEKIKTIGSTYMAATGLSQYMHIGTMVEFAYALVGKLDAIN
KHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLD
KIQVTEETSLILQTLGYTCTCTYFVN
3D structure
PDB1ab8 Structure of the adenylyl cyclase catalytic core.
ChainB
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S891 I892 S942 R1029
Catalytic site (residue number reindexed from 1) S17 I18 S68 R142
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FOK B K896 G941 S942 K22 G67 S68
BS02 FOK B F889 D1018 I1019 W1020 G1021 V1024 N1025 F15 D131 I132 W133 G134 V137 N138
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1ab8, PDBe:1ab8, PDBj:1ab8
PDBsum1ab8
PubMed9069282
UniProtP26769|ADCY2_RAT Adenylate cyclase type 2 (Gene Name=Adcy2)

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