Structure of PDB 1a5h Chain B

Receptor sequence
>1a5hB (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
IKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQ
ERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALL
QLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYS
ERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQ
GDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNM
RP
3D structure
PDB1a5h Structural mapping of the active site specificity determinants of human tissue-type plasminogen activator. Implications for the design of low molecular weight substrates and inhibitors.
ChainB
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H47 D96 Q200 G201 D202 S203 G204
Enzyme Commision number 3.4.21.68: t-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B S26 H27 W29 R119 T120 C122 E137 R206 M207 S11 H12 W14 R117 T118 C120 E135 R214 M215
BS02 BBA B D97 T98 Y99 D189 A190 S195 I213 W215 G216 G219 D91 T92 Y93 D197 A198 S203 I221 W223 G224 G226
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1a5h, PDBe:1a5h, PDBj:1a5h
PDBsum1a5h
PubMed9268299
UniProtP00750|TPA_HUMAN Tissue-type plasminogen activator (Gene Name=PLAT)

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