Structure of PDB 1a52 Chain B

Receptor sequence
>1a52B (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHERL
AQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEML
3D structure
PDB1a52 Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.
ChainB
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST B E353 L387 H524 L525 E49 L83 H220 L221 BindingDB: IC50=1.3nM,Kd=0.2nM,EC50=0.75nM,Ki=0.21nM
External links
PDB RCSB:1a52, PDBe:1a52, PDBj:1a52
PDBsum1a52
PubMed9600906
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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