Structure of PDB 1a28 Chain B

Receptor sequence
>1a28B (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
LIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQLGERQLLSVVKW
SKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAPDL
ILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPL
EGLRSQTQFEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHD
LVKQLHLYCLNTFIQSRALSVEFPEMMSEVIAAQLPKILAGMVKPLLFH
3D structure
PDB1a28 Atomic structure of progesterone complexed with its receptor.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STR B L718 N719 Q725 M756 M759 Y890 C891 L36 N37 Q43 M74 M77 Y208 C209 MOAD: Ki=5.1nM
BindingDB: Ki=3.5nM,EC50=2.9nM,IC50=>10000nM
External links
PDB RCSB:1a28, PDBe:1a28, PDBj:1a28
PDBsum1a28
PubMed9620806
UniProtP06401|PRGR_HUMAN Progesterone receptor (Gene Name=PGR)

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