Structure of PDB 6olz Chain Aj

Receptor sequence

>6olzAj (length=84) Species: 9606 (Homo sapiens)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPK

3D structure

• PDB: 6olz Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
• Chain: Aj
• Resolution: 3.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Aj	R20 R21 T59 G62 R63 M64 R65 H66 L67 Y71 R72 R73 F74 H76 R79 G81 T82 T83 P84 K85	R19 R20 T58 G61 R62 M63 R64 H65 L66 Y70 R71 R72 F73 H75 R78 G80 T81 T82 P83 K84
BS02	rna	Aj	T2 K3 G4 T5 S6 F8 G9 K10 R11 R12 N13 T15 H16 H28 Q30 R43 K44 R45 K46 Y47 N48 W49 K52 R55 R56 T58 Y71 R79	T1 K2 G3 T4 S5 F7 G8 K9 R10 R11 N12 T14 H15 H27 Q29 R42 K43 R44 K45 Y46 N47 W48 K51 R54 R55 T57 Y70 R78
BS03	ZN	Aj	C22 C34	C21 C33

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6olz, PDBe:6olz, PDBj:6olz
• PDBsum: 6olz
• PubMed: 31160784
• UniProt: P61927|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)