Structure of PDB 8p2k Chain Ah

Receptor sequence

>8p2kAh (length=206) Species: 9986 (Oryctolagus cuniculus)

GISRDNWHKRRKTGGKRKPYHKKRKYELGRPAANTKIGPRRIHTVRVRGG
NKKYRALRLDVGNFSWGSECCTRKTRIIDVVYNASNNELVRTKTLVKNCI
VLIDSTPYRQWYESHYALPLGRKKGAKLTPEEEEILNKKRSKKIQKKYDE
RKKNAKISSLLEEQFQQGKLLACIASRPGQCGRADGYVLEGKELEFYLRK
IKARKG

3D structure

• PDB: 8p2k NAC controls cotranslational N-terminal methionine excision in eukaryotes.
• Chain: Ah
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Ah	R77 R92 K124 Q168 K170 R205	R76 R91 K123 Q167 K169 R204
BS02	rna	Ah	G2 I3 R5 D6 N7 H9 K10 R11 R12 K13 T14 G16 Y21 H22 K23 K24 R25 K26 Y27 L29 R31 A33 A34 I43 H44 T45 R47 V48 R49 G50 K54 Y55 R56 L58 R59 N64 S66 C71 C72 T73 R74 K75 S86 N87 K98 N99 K143 K144 K147 K148 Y149 R178 Q181 R184 D186	G1 I2 R4 D5 N6 H8 K9 R10 R11 K12 T13 G15 Y20 H21 K22 K23 R24 K25 Y26 L28 R30 A32 A33 I42 H43 T44 R46 V47 R48 G49 K53 Y54 R55 L57 R58 N63 S65 C70 C71 T72 R73 K74 S85 N86 K97 N98 K142 K143 K146 K147 Y148 R177 Q180 R183 D185

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006412 translation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0016020 membrane
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8p2k, PDBe:8p2k, PDBj:8p2k
• PDBsum: 8p2k
• PubMed: 37347872
• UniProt: G1TJW1|RS8_RABIT Small ribosomal subunit protein eS8 (Gene Name=RPS8)