Structure of PDB 7o80 Chain Ac

Receptor sequence

>7o80Ac (length=225) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

VQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILA
TRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQA
ESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKF
VDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPSGKIGPKK
PLPDHVSIVEPKDEILPTTPISEQK

3D structure

PDB

7o80 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Ac	Q4 I5 S6 K7 K8 R9 R27 S139 G140 K141 R143 Q145 R146 A147 K151 L156 M157 I158 H159 S160 G161 D162 H174 L176 R178 Q179 V181 G183 K185 P205 D206	Q2 I3 S4 K5 K6 R7 R25 S137 G138 K139 R141 Q143 R144 A145 K149 L154 M155 I156 H157 S158 G159 D160 H172 L174 R176 Q177 V179 G181 K183 P203 D204
BS02	rna	Ac	R117 R146 K148	R115 R144 K146

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0016829	lyase activity
GO:0140078	class I DNA-(apurinic or apyrimidinic site) endonuclease activity

	Biological Process
GO:0006281	DNA repair
GO:0006412	translation
GO:0006417	regulation of translation
GO:0006915	apoptotic process
GO:0031334	positive regulation of protein-containing complex assembly
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051301	cell division
GO:2001235	positive regulation of apoptotic signaling pathway

	Cellular Component
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005819	spindle
GO:0005840	ribosome
GO:0005856	cytoskeleton
GO:0015935	small ribosomal subunit
GO:0022626	cytosolic ribosome
GO:0022627	cytosolic small ribosomal subunit
GO:0045202	synapse
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7o80, PDBe:7o80, PDBj:7o80
PDBsum	7o80
PubMed	34029205
UniProt	G1TNM3\|RS3_RABIT Small ribosomal subunit protein uS3 (Gene Name=RPS3)

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