Structure of PDB 8oit Chain Aa

Receptor sequence
>8oitAa (length=381) Species: 9606 (Homo sapiens) [Search protein sequence]
DTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELA
PLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKIN
MLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNY
SCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIP
EVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAAAQH
VNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKD
KRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGG
KGLDQLIQRLLQSADEEAIAELLDEHLKSAK
3D structure
PDB8oit Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
ChainAa
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna Aa R104 K298 F305 R306 K308 G309 A310 A311 A312 Q313 H314 N316 K317 T318 D319 R339 Q341 I342 R355 R40 K234 F241 R242 K244 G245 A246 A247 A248 Q249 H250 N252 K253 T254 D255 R275 Q277 I278 R291
BS02 rna Aa Y232 A312 R339 K343 Y168 A248 R275 K279
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0016149 translation release factor activity, codon specific
Biological Process
GO:0006412 translation
GO:0006415 translational termination
GO:0070126 mitochondrial translational termination
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8oit, PDBe:8oit, PDBj:8oit
PDBsum8oit
PubMed37141370
UniProtO75570|RF1M_HUMAN Peptide chain release factor 1, mitochondrial (Gene Name=MTRF1)

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