Structure of PDB 8oir Chain Aa

Receptor sequence

>8oirAa (length=381) Species: 9606 (Homo sapiens)

DTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELA
PLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKIN
MLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNY
SCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIP
EVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAAAQH
VNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKD
KRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGG
KGLDQLIQRLLQSADEEAIAELLDEHLKSAK

3D structure

• PDB: 8oir Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
• Chain: Aa
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Aa	R104 K298 F305 R306 K308 G309 A310 A311 A312 Q313 H314 N316 K317 T318 D319 R339 Q341 I342 R355	R40 K234 F241 R242 K244 G245 A246 A247 A248 Q249 H250 N252 K253 T254 D255 R275 Q277 I278 R291
BS02	rna	Aa	R193 T194 T195 G196 H236 R259 Q261 I263 E265 R271 Q273 R274 I275 R384 T391 Q392 D393 R394 R405 K408	R129 T130 T131 G132 H172 R195 Q197 I199 E201 R207 Q209 R210 I211 R320 T327 Q328 D329 R330 R341 K344
BS03	rna	Aa	Y232 A312 R339 K343	Y168 A248 R275 K279
BS04	rna	Aa	T195 G196 G197 Q261 S269 R271 M272 I275 H276 T277	T131 G132 G133 Q197 S205 R207 M208 I211 H212 T213

Gene Ontology

Molecular Function

• GO:0003747 translation release factor activity
• GO:0016149 translation release factor activity, codon specific

Biological Process

• GO:0006412 translation
• GO:0006415 translational termination
• GO:0070126 mitochondrial translational termination

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion

External links

• PDB: RCSB:8oir, PDBe:8oir, PDBj:8oir
• PDBsum: 8oir
• PubMed: 37141370
• UniProt: O75570|RF1M_HUMAN Peptide chain release factor 1, mitochondrial (Gene Name=MTRF1)