Structure of PDB 8oip Chain Aa

Receptor sequence

>8oipAa (length=381) Species: 9606 (Homo sapiens)

DTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELA
PLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKIN
MLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNY
SCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIP
EVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQH
VNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKD
KRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGG
KGLDQLIQRLLQSADEEAIAELLDEHLKSAK

3D structure

• PDB: 8oip Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
• Chain: Aa
• Resolution: 3.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Aa	R193 T194 T195 G196 H236 R259 Q261 R271 Q273 R274 I275 T378 R379 R384 T391 Q392	R129 T130 T131 G132 H172 R195 Q197 R207 Q209 R210 I211 T314 R315 R320 T327 Q328
BS02	rna	Aa	G311 G312 Q313 R339 K343	G247 G248 Q249 R275 K279
BS03	rna	Aa	T195 G197 Q261 S269 R271 M272 R274 I275 H276 T277	T131 G133 Q197 S205 R207 M208 R210 I211 H212 T213

Gene Ontology

Molecular Function

• GO:0003747 translation release factor activity
• GO:0016149 translation release factor activity, codon specific

Biological Process

• GO:0006412 translation
• GO:0006415 translational termination
• GO:0070126 mitochondrial translational termination

Cellular Component

• GO:0005737 cytoplasm
• GO:0005739 mitochondrion

External links

• PDB: RCSB:8oip, PDBe:8oip, PDBj:8oip
• PDBsum: 8oip
• PubMed: 37141370
• UniProt: O75570|RF1M_HUMAN Peptide chain release factor 1, mitochondrial (Gene Name=MTRF1)