Structure of PDB 6gq1 Chain AZ

Receptor sequence
>6gq1AZ (length=840) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
AFTVDQMRSLMDKVTNVRNMSVIAHVDHGKSTLTDSLVQRAGIISAAKAG
EARFTDTRKDEQERGITIKSTAISLYSEMSDEDVKEIKQKTDGNSFLINL
IDSPGHVDFSSEVTAALRVTDGALVVVDTIEGVCVQTETVLRQALGERIK
PVVVINKVDRALLELQVSKEDLYQTFARTVESVNVIVSTYADEVLGDVQV
YPARGTVAFGSGLHGWAFTIRQFATRYAKKFGVDKAKMMDRLWGDSFFNP
KTKKWTNKDTDAEGKPLERAFNMFILDPIFRLFTAIMNFKKDEIPVLLEK
LEIVLKGDEKDLEGKALLKVVMRKFLPAADALLEMIVLHLPSPVTAQAYR
AEQLYEGPADDANCIAIKNCDPKADLMLYVSKMVPTSDKGRFYAFGRVFA
GTVKSGQKVRIQGPNYVPGKKDDLFIKAIQRVVLMMGRFVEPIDDCPAGN
IIGLVGIDQFLLKTGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNANDLP
KLVEGLKRLSKSDPCVLTYMSESGEHIVAGTGELHLEICLQDLEHDHAGV
PLKISPPVVAYRETVESESSQTALSKSPNKHNRIYLKAEPIDEEVSLAIE
NGIINPRDDFKARARIMADDYGWDVTDARKIWCFGPDGNGPNLVIDQTKA
VQYLHEIKDSVVAAFQWATKEGPIFGEEMRSVRVNILDVTLHADAIHRGG
GQIIPTMRRATYAGFLLADPKIQEPVFLVEIQCPEQAVGGIYSVLNKKRG
QVVSEEQRPGTPLFTVKAYLPVNESFGFTGELRQATGGQAFPQMVFDHWS
TLGSDPLDPTSKAGEIVLAARKRHGMKEEVPGWQEYYDKL
3D structure
PDB6gq1 Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
ChainAZ
Resolution4.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna AZ H27 V28 V137 Q138 R162 P580 E737 G741 Y744 K749 R785 G789 G790 H25 V26 V135 Q136 R160 P578 E735 G739 Y742 K747 R783 G787 G788
BS02 rna AZ S47 K391 R393 Q432 R433 S45 K389 R391 Q430 R431
BS03 SO1 AZ Y521 A562 F729 M796 V797 F798 Y519 A560 F727 M794 V795 F796
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019843 rRNA binding
GO:0042802 identical protein binding
GO:0043022 ribosome binding
GO:0051087 protein-folding chaperone binding
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0045901 positive regulation of translational elongation
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6gq1, PDBe:6gq1, PDBj:6gq1
PDBsum6gq1
PubMed29886014
UniProtP32324|EF2_YEAST Elongation factor 2 (Gene Name=EFT1)

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